杨长宪 番茄功能基因组学与精准育种实验室
邮箱：changxian.yang@pku-iaas.edu.cn
研究方向：番茄重要功能基因挖掘、种质资源鉴定/创新和遗传育种
2004年09月-2011年06月，华中农业大学，博士
2017年08月-2019年08月，密歇根州立大学，访问学者/博士后
2011年07月-2022年12月，华中农业大学，讲师/副教授/教授
2023年01月-至今，北京大学现代农业研究院，研究员/课题组长(Principal Investigator /PI)
重要荣誉及奖励：
获全国百篇优秀博士毕业论文（2014，序1）、神农中华农业科技三等奖（2019，序3）、华农首届“园艺新秀”奖（2020，序1）、华耐园艺科技奖（2014，序5）、湖北省科技进步一等奖（2018，序8）等多项科研奖励。
研究工作与成果：
本实验室将围绕番茄等作物的精准设计育种相关课题开展应用基础和应用研究，利用多组学分析手段，结合全基因组关联分析、BSA-seq、图位克隆等方法克隆调控番茄品质、发育、抗性、株型等重要农艺性状的关键基因，并利用分子生物学、细胞学、组学等手段解析相关性状分子/驯化机制，通过生物设计育种并结合常规育种培育优质多抗广适番茄新品种。
发表SCI论文30余篇，其中以第一作者或通讯作者（含共同）发表在PNAS、New Phytol等国际知名杂志20余篇，被引次数1200余次。授权国家发明专利11项。主持国家基金、湖北洪山实验室重大项目、国家重点研发计划课题等近20项。担任Vegetable Res期刊编委，并常年为New Phytol、Plant Physiol等多个国际权威期刊审稿。
课题组常年招聘科研助理、副/助理研究员，欢迎加盟！
代表性论文：
1) Li Q, Shen H, Yuan S, Dai X*, Yang C*. miRNAs and lncRNAs in tomato: Roles in biotic and abiotic stress responses. Front Plant Sci, 2023, 13:1094459
2) Gao Y#, Li N#, Ruan J, Li Y, Liao X, Yang C*. Genome-wide identification, cloning and expression profile of RanBP2-Type zinc finger protein genes in tomato. Horticulturae, 2022, 8: 985
3) Xie Q, Xiong C, Yang Q, Zheng F, Larkin RM, Zhang J, Wang T, Zhang Y, Ouyang B, Lu Y, Ye J, Ye Z*, Yang C*. A novel regulatory complex mediated by Lanata (Ln) controls multicellular trichome formation in tomato. New Phytol, 2022, 236: 2294-2310
4) Zheng F, Cui L, Li C, Xie Q, Ai G, Wang J, Yu H, Wang T, Zhang J, Ye Z, Yang C*. Hair (H) interacts with SlZFP8-like to regulate the initiation and elongation of trichomes by modulating SlZFP6 expression in tomato. J Exp Bot, 2022, 73: 228–244
5) Gao S#, Li N#, Niran J, Wang F, Yin Y, Yu C, Jiao C*, Yang C*, Yao M*. Transcriptome profiling of Capsicum annuum using Illumina- and PacBio SMRT-based RNA-Seq for in-depth understanding of genes involved in trichome formation. Sci Rep, 2021, 11:10164
6) Yang Q#, Wan X#, Wang J, Zhang Y, Zhang J, Wang T, Yang C*, Ye Z*. The loss of function of HEL, which encodes a cellulose synthase interactive protein, causes helical and vine-like growth of tomato. Hortic Res, 2020, 7:180
7) Xiong C, Xie Q, Yang Q, Sun P, Gao S, Li H, Zhang J, Wang T, Ye Z, Yang C*. WOOLLY, interacting with MYB transcription factor MYB31, regulates cuticular wax biosynthesis by modulating CER6 expression in tomato. Plant J, 2020, 103: 323–337
8) Liao X#, Wang J# (co-first author), Zhu S, Xie Q, Wang L, Yu H, Ye Z, Yang C*. Transcriptomic and functional analyses uncover the regulatory role of lncRNA000170 in tomato multicellular trichome formation. Plant J, 2020, 104: 18–29
9) Xie Q, Gao Y, Li J, Yang Q, Qu X, Li H, Zhang J, Wang T, Ye Z*, Yang C*. The HD-Zip IV transcription factor SlHDZIV8 controls multicellular trichome morphology by regulating the expression of Hairless-2. J Exp Bot, 2020, 71:7132-7145
10) Xu W#, Gao S#, Song J, Yang Q, Wang T, Zhang Y, Zhang Y, Li H, Yang C*, Ye Z*. NDW, encoding a receptor-like protein kinase, regulates plant growth, cold tolerance and susceptibility to Botrytis cinerea in tomato. Plant Sci, 2020, 301:110684
11) Wang J#, Xia J#, Song Q, Liao X, Gao Y, Zheng F, Yang C*. Genome-wide identification, genomic organization and expression profiles of SlARR-B gene family in tomato. J App Genet, 2020, 61: 391–404
12) Liao X#, Wang L#, Zhu S, Zheng F, Yang C*. Identification, genomic organization, and expression profiles of single C2H2 zinc finger transcription factors in tomato (Solanum lycopersicum). J Appl Genet, 2020, 62:1-15
13) Gao S, Gao W, Liao X, Xiong C, Yu G, Yang Q, Yang C*, Ye Z*. The tomato WV gene encoding athioredoxin protein is essential for chloroplast development at low temperature and high light intensity. BMC Plant Biol, 2019, 19:265
14) Chang J, Yu T, Yang Q, Li C, Xiong C, Gao S, Xie Q, Zheng F, Li H, Tian Z, Yang C*, Ye Z*. Hair, encoding a single C2H2 zinc-finger protein, regulates multicellular trichome formation in tomato. Plant J, 2018, 96(1):90-102
15) Gao S, Gao Y, Xiong C, Yu G, Chang J, Yang Q, Yang C*, Ye Z*. The tomato B-type cyclin gene, SlCycB2, plays key roles in reproductive organ development, trichome initiation, terpenoids biosynthesis and Prodenia litura defense. Plant Sci, 2017, 262:103-114.
16) Chang J, Yu T, Gao S, Xiong C, Xie Q, Li H, Ye Z, Yang C*. Fine mapping of the dialytic gene that controls multicellular trichome formation and stamen development in tomato. Theor Appl Genet, 2016, 129: 1531-1539
17) Fan M, Gao S, Ren J, Yang Q, Li H, Yang C*, Ye Z*. Overexpression of SlRBZ results in chlorosis and dwarfism through impairing chlorophyll, carotenoid, and gibberellin biosynthesis in tomato. Front Plant Sci, 2016, 7: 907
18) Gao Y, Gao S, Xiong C, Yu G, Chang J, Ye Z, Yang C*. Comprehensive analysis and expression profile of the homeodomain leucine zipper IV transcription factor family in tomato. Plant Physiol Bioch, 2015, 96: 141-153
19) Yang C#, Gao Y# (co-first author), Gao S, Yu G, Xiong C, Chang J, Li H, Ye Z*. Transcriptome profile analysis of cell proliferation molecular processes during multicellular trichome formation induced by tomato Wov gene in tobacco. BMC Genomics, 2015, 16:868
20) Yang C, Ye Z*. Trichomes as models for studying plant cell differentiation. Cell Mol Life Sci, 2013, 70：1937-1948
21) Yang C, Li H, Zhang J, Luo Z, Gong P, Zhang C, Li J, Wang T, Zhang Y, Lu Y, Ye Z*. A regulatory gene induces trichome formation and embryo lethality in tomato. Proc Natl Acad Sci USA, 2011, 108: 11836–11841
22) Yang C, Li H, Zhang J, Wang T, Ye Z*. Fine-mapping of the woolly gene controlling multicellular trichome formation and embryonic development in tomato. Theor Appl Genet, 2011, 123: 625–633
23) Song J, Shang L, Li C, Wang W, Wang W, Zhang C, Ai G, Ye J, Yang C, Li H, Hong Z, Larkin RM, Ye Z, Zhang J*. Variation in the fruit development gene POINTED TIP regulates protuberance of tomato fruit tip. Nature Communications, 2022, online
24) Luo D, Xiong C, Lin A, Zhang C, Sun W, Zhang J, Yang C, Lu Y, Li H, Ye Z, He P, Wang T*. SlBBX20 interacts with the COP9 signalosome subunit SlCSN5-2 to regulate anthocyanin biosynthesis by activating SlDFR expression in tomato. Hortic Res, 2021, 8:163
25) Hua B, Chang J, Xu Z, Han X, Xu M, Yang M, Yang C, Ye Z, Wu S*. HOMEODOMAIN PROTEIN8 mediates jasmonate-triggered trichome elongation in tomato. New Phytol, 2021, 230: 1063-1077
26) Yu G, Li C, Zhang L, Zhu G, Munir S, Shi C, Zhang H, Ai G, Gao S, Zhang Y, Yang C, Zhang J, Li H, Ye Z*. An allelic variant of GAME9 determines its binding capacity with the GAME17 promoter in the regulation of steroidal glycoalkaloid biosynthesis in tomato. J Exp Bot, 2020, 71: 2527-2536
27) Xiong C, Luo D, Lin A, Zhang C, Shan L, He P, Li B, Zhang Q, Hua B, Yuan Z, Li H, Zhang J, Yang C, Lu Y, Ye Z, Wang T*. A tomato B-box protein SlBBX20 modulates carotenoid biosynthesis by directly activating PHYTOENE SYNTHASE 1, and is targeted for 26S proteasome-mediated degradation. New Phytol, 2019, 221: 279-294
28) Li J, Ouyang B, Wang T, Luo Z, Yang C, Li H, Sima W, Zhang J, Ye Z*. HyPRP1 Gene Suppressed by Multiple Stresses Plays a Negative Role in Abiotic Stress Tolerance in Tomato. Front Plant Sci, 2016, 7: 967
29) Luo Z, Zhang J, Li J, Yang C, Wang T, Ouyang B, Li H, Giovannoni J, Ye Z*. A STAY-GREEN protein SlSGR1 regulates lycopene and b-carotene accumulation by interacting directly with SlPSY1 during ripening processes in tomato. New Phytol, 2013, 198: 442–452
30) Zhang C, Ouyang B, Yang C, Li H, Zhibiao Ye*. Reducing AsA leads to leaf lesion and defence response in knock-down of the AsA biosynthetic enzyme GDP-D-mannose pyrophosphorylase gene in tomato plant. Plos One, 2013, 8: e61987
31) Li J, Sima W, Ouyang B, Luo Z, Yang C, Ye Z, Li H*. Identification and expression pattern of a ZPR1 gene in wild tomato (Solanum pennellii). Plant Mol Biol Rep, 2013, 31:409-417
32) Gong P, Zhang J, Li H, Yang C, Zhang C, Zhang X, Khurram Z, Zhang Y, Wang T, Fei Z, Ye Z*. Transcriptional profiles of drought-responsive genes in modulating transcription signal transduction, and biochemical pathways in tomato. J Exp Bot, 2010, 61: 3563-3575
代表性专利：
1）叶志彪、杨其洪、杨长宪、张俊红、张余洋、欧阳波、王涛涛、李汉霞. 控制番茄果实形状的基因及克隆方法和应用。ZL201910407865.2
2）杨长宪、廖晓利、张俊红、张余洋、王涛涛、欧阳波、卢永恩、叶志彪. 表皮毛特异积累花青素调控基因及克隆方法和应用。ZL201911359833.6
3）叶志彪、解庆敏、杨长宪、张俊红、张余洋、王涛涛、欧阳波、李汉霞、卢永恩.番茄茸毛调控基因的克隆及应用。ZL201911359832.1
4）杨长宪、叶志彪、廖晓利、朱顺华、裴利菲、王涛涛、李汉霞。一种调控番茄腺毛形成的基因及克隆方法。ZL201811126376.1
5）杨长宪、熊程、张俊红、张余洋、王涛涛、欧阳波、卢永恩、叶志彪。蜡质调控基因SlMYB31及克隆方法和应用。ZL201911359861.8
6）杨长宪、解庆敏、叶志彪、张俊红、张余洋、王涛涛、欧阳波、李汉霞、卢永恩。一种调控番茄茸毛的hl-2基因及其应用。ZL201911359859.0
7）叶志彪、解庆敏、杨长宪、张俊红、张余洋、王涛涛、欧阳波、李汉霞、卢永恩。番茄茸毛调控基因的克隆及应用。ZL201911359832.1
8）叶志彪，杨长宪，常江，朱顺华，解庆敏 一个调控番茄腺毛形成的关键基因H的克隆及应用，2018.1.30，中国，201710914434.6
9）叶志彪,王涛涛,杨长宪. 控制番茄表皮毛发生的关键基因SlCycB2的克隆与鉴定, 2014.5.19, 中国, CN201410214017.7
10）李汉霞,杨长宪,叶志彪,王涛涛,张俊红,张余洋,卢永恩.一个控制番茄茸毛发生的关键基因Wo的克隆及应用,2010.7.20, 中国, CN201010234223.6
11）叶志彪、葛乃蓬、李汉霞、王涛涛、张俊红、张余洋、杨长宪.双重SNP标记在番茄黄化曲叶病抗病基因检测中的应用，2014.06.18，中国，CN103866027B