秦国臣 质谱分析（蛋白质组与代谢组）平台主任
邮箱：guochen.qin@pku-iaas.edu.cn
研究方向：作物蛋白质组与代谢组质谱分析方法的开发与应用
个人简介：
2013年09月-2017年07月，中科院上海生科院植物逆境生物学研究中心，博士
2017年07月-2021年07月，中科院分子植物科学卓越创新中心，博士后
2021年07月-至今，北京大学现代农业研究院，质谱分析平台主任，研究员
主持基金项目：
1）国家重点研发计划“农业生物种质资源挖掘与创新利用”重点专项青年科学家项目（2023.12.-2027.11），200万，主持
2）山东省重点人才工程项目（泰山学者青年专家岗位）（2023.1-2025.12），75万，主持
3）山东省自然科学基金青年项目（2023.1-2025.12），15万，主持
研究领域：
现代质谱仪拥有更快的扫描速度和超高的分辨率，已被广泛用于生命科学研究的多个领域。色谱质谱联用仪是当前高通量测定生物体内蛋白质组和代谢组变化的最佳分析设备，是系统生物学研究不可或缺的重要工具。
北京大学现代农业研究院质谱分析平台拥有多种质谱分析仪器，包括超高分辨率液相色谱质谱分析系统、三重四极杆气相色谱质谱分析系统等。我们依托院质谱分析平台，以农作物为主要分析样本，开发适用于现代农业基础研究的质谱分析技术，并着力构建主要农作物蛋白质组以及代谢组数据库。我们的主要研究方向包括作物蛋白质组学和代谢组学分析方法开发，农作物重要品质的质谱检测分析，关键农艺性状的多组学大队列深度分析，为现代农业发展提供分析技术支撑。
发表论文：
1. Hua Zhou, Haiyue Zeng, Tingting Yan, Sunlu Chen, Ying Fu, Guochen Qin, Xianhai Zhao, Yueqin Heng, Jian Li, Fang Lin, Dongqing Xu, Ning Wei, Xing Wang Deng. Light regulates nuclear detainment of intron-retained transcripts through COP1-spliceosome to modulate photomorphogenesis. Nature communications, 2024 Jun 15;15(1):5130. doi: 10.1038/s41467-024-49571-9. PMID: 38879536.
2. Yongqiang Yu, Wenxin Tang, Wenwei Lin, Wei Li, Xiang Zhou, Ying Li, Rong Chen, Rui Zheng, Guochen Qin, Wenhan Cao, Patricio Pérez-Henríquez, Rongfeng Huang, Jun Ma, Qiqi Qiu, Ziwei Xu, Ailing Zou, Juncheng Lin, Liwen Jiang, Tongda Xu, Zhenbiao Yang. ABLs and TMKs are co-receptors for extracellular auxin. Cell, 2023 Dec 7;186(25):5457-5471.e17. doi: 10.1016/j.cell.2023.10.017. Epub 2023 Nov 17. PMID: 37979582.
3.Guochen Qin, Menghuan Qu, Bei Jia, Wei Wang, Zhoujun Luo, Chun-Peng Song, W. Andy Tao, Pengcheng Wang. FAT-switch-based quantitative S-nitrosoproteomics reveals a key role of GSNOR1 in regulating ER functions. Nature communications, 2023, 14, 3268. https://doi.org/10.1038/s41467-023-39078-0.
4.Chenglin Jiang. Ju Sun, Rui Li, Shijuan Yan, Wei Chen, Liang Guo, Guochen Qin, Pengcheng Wang, Cheng Luo, Wenjie Huang, Qinghua Zhang, Alisdair R. Fernie, David Jackson, Xiang Li, Jianbing Yan. A reactive oxygen species burst causes haploid induction in maize. Molecular Plant. 2022, 15(6):943-955. doi: 10.1016/j.molp.2022.04.001. PMID: 35395409.
5. Mingjing Wang, Hailong Zhang, Xiaonan Zhao, Jingwen Zhou, Guochen Qin, Yuqi Liu, Xiaoyue Kou, Zhenjie Zhao, Tao Wu, Jian-Kang Zhu, Xianzhong Feng, Lixin Li. SYNTAXIN OF PLANTS81 regulates root meristem activity and stem cell niche maintenance via ROS signaling. Plant Physiology. 2022, kiac530. doi: 10.1093/plphys/kiac530. PMID: 36427205.
6. Quanzi Bai†, Wenjing Yang† (co-first author), Guochen Qin, Baolin Zhao, Liangliang He, Xuan Zhang, Weiyue Zhao, Dian Zhou, Ye Liu, Yu Liu, Hua He, Million Tadege, Yan Xiong, Changning Liu, Jianghua Chen. Multidimensional Gene Regulatory Landscape of Motor Organ Pulvinus in the Model Legume Medicago truncatula. International Journal of Molecular Sciences. 2022, 23(8):4439. doi: 10.3390/ijms23084439. PMID: 35457256.
7. Liwen Fu†, Yanlin Liu† (co-first author), Guochen Qin, Ping Wu, Hailing Zi, Zhongtian Xu, Xiaodi Zhao, Yue Wang, Yaxing Li, Shuhui Yang, Chao Peng, Catherine C.L. Wong, Sang-Dong Yoo, Renyi Liu, Young-Hee Chu, Yan Xiong. The TOR-EIN2 axis mediates nuclear signaling to modulate plant growth. Nature, 2021, 591. https://doi.org/10.1038/s41586-021-03310-y
8. Jie Yang, Hang He, Yuming He, Qiaozhen Zheng, Qingzhong Li, Guochen Qin, Pengchen Wang, Chao Peng, Yangtao Gu, Yang Zhao, Mingzhang Wen, Rong Chen, Tongda Xu. TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (24). https://doi.org/10.1073/pnas.2102544118
9. Li Guan, Shurui Yang, Shenglin Li, Yu Liu, Yuqi Liu, Yi Yang, Guochen Qin, Haihai Wang, Tao Wu, Zhigang Wang, Xianzhong Feng, Yongrui Wu, Jian-Kang Zhu, Xugang Li, Lixin Li. AtSEC22 Regulates Cell Morphogenesis via Affecting Cytoskeleton Organization and Stabilities. Frontiers in Plant Science, 2021, 12: 635732. DOI: 10.3389/fpls.2021.635732
10. Qian Wang†, Guochen Qin† (co-first author), Min Cao, Rong Chen, Yuming He, Liyuan Yang, Zhejun Zeng, Yongqiang Yu, Yangtao Gu, Weiman Xing, W. Andy Tao, Tongda Xu. A phosphorylation-based switch controls TAA1-mediated auxin biosynthesis in plants. Nature Communications, 2020, 11, 679. https://doi.org/10.1038/s41467-020-14395-w
11. Pan Liu, Wen-Feng Nie, Xiansong Xiong, Yuhua Wang, Yuwei Jiang, Pei Huang, Xueqiang Lin, Guochen Qin, Huan Huang, Qingfeng Niu, Jiamu Du, Zhaobo Lang, Rosa Lozano-Duran, Jian-Kang Zhu. A novel protein complex that regulates active DNA demethylation in Arabidopsis.Journal of Integrative Plant Biology, 2020. https://doi.org/10.1111/jipb.13045
12. Guochen Qin, Jun Ma, Xiaomei Chen, Zhaoqing Chu, Yi-Min She. Methylated-antibody affinity purification to improve proteomic identification of plant RNA polymerase Pol V complex and the interacting proteins. Scientific Reports, 2017, 7: 42943
13.Jingjing Fang, Guochen Qin, Jun Ma, Yi-Min She. Quantification of plant cell wall monosaccharides by reversed-phase liquid chromatography with 2-aminobenzamide pre-column derivatization and a non-toxic reducing reagent 2-picoline borane. Journal of Chromatography A, 2015, 1414:122-128
14. Guochen Qin, Qitian Wang, Jin Hu, Zhan Li, Fei He, Jiancheng Wang. Changes in seed quality and ABA content during seed development in sponge gourd (Luffa cylindrica). Seed Science and Technology, 2013, 41: 398-406.