刘晓芹 花生功能基因组学与种质资源创新实验室主任
邮箱：xiaoqin.liu@pku-iaas.edu.cn
研究方向：花生优良性状基因的遗传定位与功能解析、果针向地性和荚果发育的遗传调控机制、种质资源创新与分子设计育种
个人简介：
2010.09-2015.06，南京农业大学，博士
2015.07-2018.06，北京大学，博士后
2018.07-2019.01，山东农业大学，副教授
2018.11-2021.02，美国普渡大学，博士后
2021.03-至今， 北京大学现代农业研究院，研究员
主要荣誉：
2022年 全国青年岗位能手
2021年 山东省“泰山学者”青年专家
2022年 潍坊市三八红旗手
主要研究领域：
花生又名落花生、长生果，是典型的地上开花地下结果的油料作物，花生开花受精之后果针开始伸长并呈现向地性生长的特性，进而将子房带入地下，经受土壤的机械压力刺激、光转暗和营养环境等一系列非生物胁迫，到达一定深度的土壤后子房开始膨大并发育成荚果。随着国内外对花生需求量的逐渐增加，改良花生品种和发展花生产业对保障我国植物食用油安全具有重要的战略意义。本实验室将根据前期研究工作，利用全基因组重测序、转录组测序及全基因组关联分析等组学技术，结合图位克隆及分子生物学方法定位、克隆和功能验证调控花生重要农艺性状的关键基因。以期实现花生种质资源创新及高产优质新品种的培育。研究内容如下：
1.以自然群体、遗传群体和诱变群体为研究对象，结合多组学方法对控制花生重要农艺性状的关键基因/QTL进行定位和功能验证；
2.光信号和土壤机械刺激对荚果发育的遗传调控研究；
3.植物激素参与果针向地性和荚果膨大的信号网络调控；
4.解析花生根瘤固氮和营养高效吸收利用的分子机制；
5.利用常规育种与分子设计育种相结合的方法培育高产优质高抗花生新品种。
代表性论文：
（#通讯作者；*第一作者）
1. Cui Y, SuY, Bian J, Han X, Guo H, Yang Z, ChenY, Li L, Li T, Deng XW, Liu X#. Single-nucleus RNA and ATAC sequencing analyses provide molecular insights into early pod development of peanut fruit. Plant Com. (2024). doi: https://doi.org/10.1016/ j.xplc.2024.100979.
2. Wang W, BianJ, CuiY, GuoH, HeL, LiuX, LiZh, MaJ, LiuX#. Determgination of the regulatory network of two bZIP transcription factors, AhHYH and AhHY5, in light signal regulation in peanut by DAP-seq. Curr Plant Biol. (2024). Volume 38, June 2024, 100352.
3. Pan J, Li X, Fu C, Bian J, Wang Z, Yu C, Liu X, Wang G, Tian R, Song X, Li C, Xia H, Zhao S, Hou L, Meng G, Wang X, Zhao C. (2024). High‑density bin‑based genetic map reveals a 530‑kb chromosomesegment derived from wild peanut contributing to late leaf spotresistance. TAG.137:69
4.Bian J, Cui Y, Li J, Guan Y, Tian S, Liu X#.(2023).Genome-wide analysis of PIN genes in cultivated peanuts (Arachis hypogaea L.): identification, subcellular localization, evolution, and expression patterns. BMC Genomics 24:629.
5. Chen X, Liu Y, Lv K, Wang M, Liu X, Li B.(2023). FASTdRNA: a workflow for the analysis of ONT direct RNA sequencing.Bioinform Adv. Jul 20;3(1).
6. Tao J, Wu F, Wen H, Liu X, Luo W, Gao L, Jiang Z, Mo B, Chen X, Kong W, Yu Y.(2023).RCD1 Promotes Salt Stress Tolerance in Arabidopsis by Repressing ANAC017 Activity.Int J Mol Sci.Jun 6;24(12):9793.
7. Cui Y, Bian J, Guan Y, XuF, Han X, Deng X W#, and Liu X#. (2022). Genome-Wide Analysis and Expression Profiles of Ethylene Signal Genes and Apetala2/Ethylene-Responsive Factors in Peanut (Arachis hypogaea L.). Front. Plant Sci.March 17; 13:828482.
8. Cui Y, Bian J, Lv Y, Li J, Deng X W#, and Liu X#. (2022). Analysis of the Transcriptional Dynamics of Regulatory Genes During Peanut Pod Development Caused by Darkness and Mechanical Stress. Front. Plant Sci. May 26; 13:904162.
9. Yang G, Deng P, Guo Q, Shi T, Pan W, Cui L, Liu X#,Nie X#.(2022). Population transcriptomic analysis identifies the comprehensive lncRNAs landscape of spike in wheat (Triticum aestivum L.). BMC Plant Biology. August 01; 22: 450.2022.22:450.
10. Lei P, Ai Q, Xiong Z, Lu J, Wei X, Song W, Liu X#, Nie X#.(2022). Patterns and impacting factors of gene evolutionary rate between wild and cultivated 2 emmer wheat (Triticum turgidum. L). Journal of Systematics and Evolution.April 08;doi: 10.1111/jse.12852.
11. Zhou X, J Condori-Apfata, Liu X, S Condori-Pacsi, M Valderrama Valencia, Zhang C. (2021). Transcriptomic Changes Induced by Drought Stress in Hardneck Garlic during the Bolting/Bulbing Stage. Agronomy. January ;11: 246.
12. Zhou X, Dou Y, Huang X, Li G, Zhang H, Jiang D, J Condori-Apfata, Liu X, S Condori Pacsi, R Alvarez, M Elizabeth Mayta Anco, H Rodriguez, M Valencia, Zhang C. (2021). Using Principal Component Analysis and RNA-Seq to Identify Candidate Genes that Control Salt Tolerance in Garlic (Allium sativum L.). Agronomy. April;11(4):691
13. Chen J*, Liu X*, Liu S, Fan X, Zhao L, Song M, Fan X, Xu G. (2020). Co-overexpression of OsNAR2.1 and OsNRT2.3a increased agronomic nitrogen use efficiency in transgenic rice plants. Frontiers in Plant Science. Aug 01; 11: 1245.
14. S D. Daba, Liu X, U Aryal, M Mohammadi. (2020). A Proteomic Analysis of Grain Yield Related Traits in Wheat. AoB PLANTS. August 24; 12: plaa042.
15. Liu X, Liu R, Yue L, Zhong S, Shi H. (2017).EIN3 and PIF3 Form an Interdependent Module that Represses Chloroplast Development in Buried Seedlings. The Plant Cell. November 07; 29: 3051-3067.
15. Liu X, Li Y, Zhong S. (2017).Interplay between Light and Plant Hormones in the Control of Arabidopsis Seedling Chlorophyll Biosynthesis. Frontiers in Plant Science. August 17; 8: 1433.
16. Liu X, Feng H, Huang D, Fan X, Xu G.(2015). Two short sequences in the promoter of OsNAR2.1 are necessary for fully activating the nitrate induced gene expression in rice. Scientific Reports. July 07; 5:11950.
17. Liu X, Huang D, Tao J, M AJ, Fan X, Xu G. (2014).Identification and functional assay of the interaction motifs in the partner protein OsNAR2.1 of the two-component system for high-affinity nitrate transport. New Phytologist. Aug 01;204: 74-80.
18. Feng H, Fan X, Liu X, S QR, M AJ, Xu G. (2011).Multiple roles of nitrate transport accessory protein NAR2 in plants. Plant Signal and Behaviour. September 01, 6: 1286-1289.
授权专利：
花生启动子及其应用，2022, ZL 202210193478.5
地方标准：
1. 绿色高油酸花生种植技术规程，TYXZZ 001-2024
2. 高油酸花生油低温压榨生产技术规程，TYXZZ 002-2024