侯书国 作物先天免疫理论与应用创新实验室主任
邮箱：shuguo.hou@pku-iaas.edu.cn
研究方向：作物先天免疫、植物肽信号调控
个人简介：
学习情况
2018.5-2019.5, 得克萨斯农工大学, 生物化学与生物物理系，博士后
2017.2-2018.3, 得克萨斯农工大学, 生物化学与生物物理系, 访问学者
2012.9–2015.7, 山东大学, 生命科学学院，细胞生物学, 博士
2003.9–2006.7, 东北师范大学, 生命科学学院，细胞生物学, 硕士
1999.9–2003.7, 东北师范大学, 生命科学学院，生物科学, 学士
工作情况
2022.11-至今，北京大学现代农业研究院/潍坊现代农业山东省实验室，研究员
2007.10-至今, 山东建筑大学，研究员
2006.7-2007.9, 北京生命科学研究所, 科研助理
研究工作：
（1） 分泌肽和受体激酶调控的作物抗病信号转导
以小麦、番茄和拟南芥为研究对象，利用生物信息学、组学和生物化学等方法鉴定植物免疫调控分泌小肽及受体，分析小肽-受体调控植物抗病和感病的作用机理，在此基础上培育作物抗病新品种。
（2） 植物天然诱抗剂和菌剂的开发与应用
筛选作物抗病诱导小肽，通过生物发酵和合成等工艺制备用于提高作物抗病的免疫诱导剂；分离和基因工程改造植物促生长内生菌，开发用于提高作物抗性的微生物菌剂。
（3）病原菌致病因子毒性机理
以禾谷镰刀菌、西瓜嗜酸菌等植物病原微生物为研究对象，通过比较基因组学和蛋白质组学等方法鉴定病原微生物致病因子，揭示致病因子毒性机理。
研究成果：
发表论文30余篇，其中以第一作者或通讯作者在Nature、Nature Communications、Trends in Plant Science、PLoS Pathogens等国际著名期刊上发表论文16篇，主持国家自然科学基金等省部级以上课题6项，获得山东省高校优秀科研成果奖、山东大学研究生优秀学术成果奖、Stress Biology优秀论文奖等多项。
代表性论文：（#第一作者、*通讯作者）
1. Jia F#, Xiao Y#*, Feng Y#, Yan J, Fan M, Su Y, Huang S, Li W, Zhao T, Han Z, Hou, S*, Chai J*. N-glycosylation facilitates the activation of a plant cell-surface receptor. Nature Plants, 2024 Nov 7. doi: 10.1038/s41477-024-01841-6.
2. Wang L, Liu Y*, Hou S*. DGK5 phosphorylation finetunes PA homeostasis in plant immunity. Trends Plant Sci, 2024 Apr 2:S1360-1385(24)00088-8.
3. Hou S*, Rodrigues O, Liu Z, Shan L, He P*. Small holes, big impact: Stomata in plant-pathogen-climate epic trifecta. Molecular Plant, 2023 Dec 1:S1674-2052(23)00394-5.
4. Liu Z#, Hou S#, He P. Detection of Ligand-Induced Receptor Kinase and Signaling Component Phosphorylation with Mn2+-Phos-Tag SDS-PAGE. Methods in Molecular Biology, 2024;2731:205-214.
5. Liu Y*, Hou S*, Chen S. Kinase fusion proteins: intracellular R-proteins in plant immunity. Trends in Plant Science, 2023 Nov 27:S1360-1385(23)00361-8.
6. Liu Y*, Hou S*. Bacteria manipulate host cells with channel-forming effectors. Trends in Microbiology, 2023 Nov 10:S0966-842X(23)00302-5.
7. Cheng C, Wu Q, Wang M, Chen D, Li J, Shen J, Hou S, Zhang P, Qin L, Acharya BR, Lu X, Zhang W. Maize MITOGEN-ACTIVATED PROTEIN KINASE 20 mediates high-temperature-regulated stomatal movement. Plant Physiology, 2023 Nov 22;193(4):2788-2805.
8. Liu Z#, Hou S#*, Rodrigues O, Wang P, Luo D, Munemasa S, Lei J, Liu J, Ortiz-Morea FA, Wang X, Nomura K, Yin C, Wang H, Zhang W, Zhu-Salzman K, He SY, He P*, Shan L*. Phytocytokine signaling reopens stomata in plant immunity and water loss. Nature, 2022, 279:153832.
9. Hou S#*, Liu D#, Huang S#, Luo D, Liu Z, Wang P, Mu R, Han Z, Chai J, Shan L*, He P*. The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes. Nature Communications 2021, 12(1):5494.
10. Hou S, Wang X, Chen D, Yang X, Wang M, David T, Antonio DP, Zhang W*, The secreted peptide PIP1 amplifies immunity through receptor-Like Kinase 7. PLoS Pathogens, 2014, 10(9): 0~e1004331.
11. Hou S*, Yin C, He P*. Cleave and unleash: metacaspases prepare Peps for work. Trends in Plant Science 2019, 24(9):787-790.
12. Hou S*, Huang Y. THESEUS1 activation upon stresses: a ligand threshold model. Trends in Plant Science 2022, 27(9):831-833.
13. Hou S*, Liu Z, Shen H, Wu D*. Damage-associated molecular pattern-triggered immunity in plants. Frontier in Plant Science 2019,10:646.
14. Wang X#, Hou S#, Wu Q, Lin M, Wu D, Zhang W*. IDL6-HAE/HSL2 impacts pectin degradation and resistance to Pseudomonas syringae pv tomato DC3000 in Arabidopsis leaves. The Plant Journal 2017, 89(1):250~263.
15. Zhang J, Li Y, Bao Q, Wang H, Hou S*, Plant elicitor peptide 1 fortifies root cell walls and triggers a systemic root-to-shoot immune signaling in Arabidopsis. Plant Signaling & Behavior. 2022 Feb 15:2034270.
16. Zhang J, Zhao JX, Bao Q, Li Y, Wang H, Hou S*, EWR1 as a SCOOP peptide activates MIK2-dependent plant immunity. Journal of Plant Interactions, 2022, 17: 562-568.
17. Liu X, Liang C, Hou S, Wang X, Chen D, Shen J, Zhang W, Wang M. The LRR-RLK Protein HSL3 regulates stomatal closure and the drought stress response by modulating hydrogen peroxide homeostasis. Frontier in Plant Science 2020 11:548034.
18. Hou S#, Liu D#, He P*, Phytocytokines function as immunological modulators of plant immunity. Stress Biology 1, 8 (2021). Doi: 0.1007/s44154-021-00009-y.中国科技期刊卓越计划.
19. Hou S*, Zhang J, He P*, Stress-induced activation of receptor signaling by protease-mediated cleavage. Biochemical Journal 2021, 478:1847-1852.
20. Hou S*, Shen H, Shao H. PAMP-Induced Peptide 1 cooperates with salicylic acid to regulate stomatal immunity in Arabidopsis thaliana. Plant Signaling & Behavior 2019, 14(11):1666657.
21. Hou S, Jamieson P, He P*. The cloak, dagger, and shield: proteases in plant– pathogen interaction. Biochemical Journal 2018.08.16, 475(8): 2491~2509.
22. Mei S, Hou S, Cui H, Feng F, Rong W*. Characterization of the interaction between Oidium heveae and Arabidopsis thaliana. Molecular Plant Pathology 2016, 17(9): 1331~1343.
23. Wang Y, Li J, Hou S, Wang X, Li Y, Ren D, Chen S, Tang X, Zhou J*. A Pseudomonas syringae ADP-ribosyltransferase inhibits Arabidopsis mitogen-activated protein kinase kinases. The Plant Cell 2010, 22(6): 2033~2044.
24. Hou S*, Zhang C, Yang Y, Wu D. Recent advances in plant immunity: recognition, signaling, response, and evolution. Biologia Plantarum 2013, 57(1): 11-25.
25. Hou S*, Zhang W, Zhang C, Wu D, One-step expression and tyrosine O-sulfonation of Ax21 in Escherichia coli. Applied Biochemistry and Biotechnology 2012, 166(5): 1368~1379.
26. Hou S*, Mu R, Ma G, Xu X, Zhang C, Yang y, Wu D, Pseudomonas syringae pv. phaseolicola effector HopF1 inhibits pathogen-associated molecular pattern-triggered immunity in a RIN4-independent manner in common bean (Phaseolus vulgaris). FEMS Microbiology Letters 2011,323(1): 35-43.
27. Hou S*, Yang Y, Wu D, Zhang C, Plant immunity evolutionary insights from PBS1, Pto and RIN4. Plant Signaling & Behavior 2011, 6(6): 794~799.
承担项目：
1. PCK1-PCKR1-PKRA1 调控小麦对细菌性条斑病抗性的分子机制，国家自然科学基金面上项目（32472567），主持，50万元，2025.01-2028.12.
2. 小麦免疫调控肽激素鉴定和功能解析，山东省自然科学基金重大基础研究项目（ZR2024ZD07），主持，160万元，2025.01-2028.12.
学术兼职及社会职务：
山东省高校优秀青年创新团队带头人、Frontier in Plant Science审稿编辑、Frontier in Microbiology审稿编辑。