李磊 资深研究员 小麦雄蕊发育机智研究与应用实验室主任
邮箱：lei.li@pku-iaas.edu.cn
研究方向：一、小麦雄蕊发育的调控机制；二、铜信号在植物发育与环境适应中的转导机制与功能。
个人简介：
2007年 - 2014年，美国弗吉尼亚大学生物系，助理教授、博士生导师
2014年 - 2024年，北京大学生命科学学院、北京大学现代农学院、北大-清华联合生命中心研究员、博士生导师
2024年-至今，北京大学现代农业研究院、潍坊现代农业山东省实验室资深研究员
主要荣誉：
2012 北京市海外高层次人才，北京市特聘专家
2024 山东泰山学者特聘专家
研究领域：
目前团队主要采用分子、生化、遗传及细胞的手段重点探索两个研究方向：（1）小麦雄蕊发育的环境互作与遗传机制；（2）铜信号的转导机制与生物功能。这些研究旨在加深和拓展对植物特有生命规律的认识，为农业生物技术提供新的理论基础与操作思路。
本实验室招收博士后、助理/副研究员，热忱欢迎有志青年学者加入！
研究成果和科研项目：
主持及参与了国家重点研发计划、国家自然科学基金委创新群体项目、国家自然科学基金委面上项目等多个项目。近5年在Plant Cell、PNAS、Developmental Cell、Nucleic Acids Research、Current Biology、Nature Communications、New Phytologist等国际知名期刊发表通讯或共同通讯作者论文20余篇。
代表性论著（*通讯作者）：
1. Zhang H, Xiao L, Qin S, Wan M, Shen F, Zhao J, Li L* (2025) Polarized pectin accumulation regulates differential hypocotyl elongation at the dark-to-light transition. Current Biology, 35(3):699-707.
2. Liu C, Li A, Guo Z, Chen N, Wang Y, Tang W, Wu Y, Liu J, Wang Z, Li L*, He XQ* (2024) MicroRNA analysis reveals 2 modules that antagonistically regulate xylem tracheary element development in Arabidopsis. The Plant Cell, 37(1):koaf011.
3. Yang Y, Xu L, Hao C, Wan M, Tao Y, Zhuang Y, Su Y, Li L* (2024) The microRNA408-plantacyanin module balances plant growth and drought resistance by regulating reactive oxygen species homeostasis in guard cells. The Plant Cell, 36(10):4338-4355.
4. Hao Y, Yang Y, Tu H, Guo Z, Chen P, Chao X, Yuan Y, Wang Z, Miao X, Zou S, Li D, Yang Y, Wu C, Li B, Li L*, Cai H* (2024) A transcription factor complex in Dictyostelium enables adaptive changes in macropinocytosis during the growth-to-development transition. Developmental Cell, 59(5):645-660.
5. Shen F, Qin Y, Wang R, Huang X, Wang Y, Gao T, He J, Zhou Y, Jiao Y, Wei J*, Li L*, Yang X* (2023) Comparative genomics reveals a unique nitrogen-carbon balance system in Asteraceae. Nature Communications, 14(1):4334.
6. Xu L, Tang Y, Yang Y, Wang D, Wang H, Du J, Bai Y, Su S, Zhao C*, Li L* (2023) Microspore expressed SCULP1 is required for p-coumaroylation of sporopollenin, exine integrity, and pollen development in wheat. New Phytologist, 239(1):102-115.
7. Gao Z, Li J, Li L, Yang Y, Li J, Fu C, Zhu D, He H, Cai H, Li L* (2022) Structural and functional analyses of hub microRNAs in an integrated gene regulatory network of Arabidopsis. Genomics Proteomics Bioinformatics, 20(4):747-764.
8. Guo Z, Kuang Z, Tao Y, Wang H, Wan M, Hao C, Shen F, Yang, X*, Li L* (2022) Miniature inverted-repeat transposable elements drive rapid microRNA diversification in angiosperms. Molecular Biology and Evolution, 39(11):msac224.
9. Yang Y, Hao C, Du J, Xu L, Guo Z, Li D, Cai H, Guo H, Li L* (2022) The carboxy terminal transmembrane domain of SPL7 mediates interaction with RAN1 at the endoplasmic reticulum to regulate ethylene signaling in Arabidopsis. New Phytologist, 236(3):878-892.
10. Hao C, Yang Y, Du J, Deng XW*, Li L* (2022) The PCY-SAG14 phytocyanin module regulated by PIFs and miR408 promotes dark-induced leaf senescence in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America, 119(3):e2116623119.
11. Guo Z, Kuang Z, Zhao Y, Deng Y, He H, Wan M, Tao Y, Wang D, Wei J, Li L*, Yang X* (2022) PmiREN2.0: from data annotation to functional exploration of plant microRNAs. Nucleic Acids Research, 50(D1):D1475-D1482.
12. Jiang A, Guo Z, Pan J, Zhuang Y, Zuo D, Hao C, Gao Z, Xin P, Chu J, Zhong S, Li L* (2021) The PIF1-MIR408-Plantacyanin repression cascade regulates light dependent seed germination. The Plant Cell, 33(5):1506-1529.
13. Zhang H, Guo Z, Zhuang Y, Suo Y, Du J, Gao Z, Pan J, Li L, Wang T, Xiao L, Qin G, Jiao Y, Cai H, Li L* (2021) MicroRNA775 promotes intrinsic leaf size and reduces cell wall pectin level via a target galactosyltransferase in Arabidopsis. The Plant Cell, 33(3):581-602.
14. Zhuang Y, Zuo D, Tao Y, Cai H*, Li L* (2020) Laccase3-based extracellular domain provides possible positional information for directing Casparian strip formation in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America, 117:15400-15402.
15. Guo Z, Kuang Z, Wang Y, Zhao Y, Tao Y, Cheng C, Yang J, Lu X, Hao C, Wang T, Cao X, Wei J, Li L*, Yang X* (2020) PmiREN: a comprehensive encyclopedia of plant miRNAs. Nucleic Acids Research, 48:D1114-D1121.