研究员 - 北京大学现代农业研究院

焦成智作物基因组学与分子设计育种课题组组长

邮箱：chengzhi.jiao@pku-iaas.edu.cn

研究方向：作物基因组学、小麦品质和耐逆性状遗传解析、分子设计育种

个人简介：

2009年9月-2013年7月山东农业大学学士

2013年9月-2016年7月山东农业大学硕士

2016年7月-2020年8月北京诺禾致源科技股份有限公司生信工程师

2020年9月-2024年12月中国农科院作科所与南京农业大学联合培养博士

2020年10月-2024年12月天津极智生物科技有限公司总经理

2025年1月-至今北京大学现代农业研究院青年研究员、课题组长（PI）

研究工作与成果：

课题组聚焦作物基因组育种方向，利用高通量测序技术和生物信息分析等手段，挖掘和解析优良的基因组结构变异，并通过GS和基因编辑等生物技术进行智能设计育种。研究重点包括：（1）通过构建小麦等主要作物的T2T基因组、泛基因组和群体基因组，挖掘丰富的遗传变异，并利用生信方法进行优良性状定位，系统地解析优异单倍型演化规律；（2）开发基于机器学习和深度学习的育种分析算法和工具，搭建作物多组学育种数据库和育种导航系统；（3）通过全基因组选择和基因编辑等技术，进行快速育种选择和性状定向改良。

课题组已发表SCI论文20多篇，其中以第一作者或通讯作者（含共同）在Nature、PNAS、Nature Plants、Molecular Plant、Plant Communications、Plant Biotechnology Journal、Science China-Life Sciences等期刊发表10余篇高质量研究论文，参与合作发表10余篇论文。以第一发明人申请并获得4项基因组学分析方法和育种算法相关发明专利。担任多个SCI期刊审稿人。

代表性论文：

（第一作者^*；通讯作者^#）

1. Chengzhi Jiao^*, Xiaoming Xie^*, Chenyang Hao^*, Liyang Chen^*, Yuxin Xie, Vanika Garg, Li Zhao, Zihao Wang, Yuqi Zhang, Tian Li, Junjie Fu, Annapurna Chitikineni, Jian Hou, Hongxia Liu, Girish Dwivedi, Xu Liu, Jizeng Jia, Long Mao, Xiue Wang, Rudi Appels, Rajeev K. Varshney^#, Weilong Guo^# & Xueyong Zhang^#. Pangenome bridges wheat structural variations with habitat and breeding. Nature, 2025 Jan; 637(8045):384–393. Doi:10.1038/s41586-024-08277-0. (第一作者)

2. Chengzhi Jiao^*, Chenyang Hao^*, Tian Li^*, Abhishek Bohra, Lanfen Wang, Jian Hou, Hongxia Liu, Hong Liu, Jing Zhao, Yamei Wang, Yunchuan Liu, Zhiwei Wang, Xin Jing, Xiue Wang, Rajeev K. Varshney^#, Junjie Fu^#, Xueyong Zhang^#. Fast integration and accumulation of breeding beneficial alleles through AB-NAMIC strategy in wheat. Plant Communications, 2023 May 8;4(3):100549. Doi: 10.1016/j.xplc.2023.100549. (第一作者)

3. Chengzhi Jiao^*, Mingxing Wen^*, Xin Jing, Vanika Garg, Chuanqing Zhou, Liyang Chen, Fengfeng Xu, Chenyang Hao, Jin Xiao, Haiyan Wang, Rajeev K. Varshney, Xueyong Zhang, Xiue Wang. Accumulation of beneficial haplotypes in Huang-Huai-Hai wheat region and its application in molecular breeding. Journal of Integrative Agriculture, 2024, ISSN 2095-3119. Doi.org/10.1016/j.jia.2024.12.003. (第一作者)

4. Chenyang Hao^*, Chengzhi Jiao^*, Jian Hou, Tian Li, Hongxia Liu, Yuquan Wang, Jun Zheng, Hong Liu, Zhihong Bi, Fengfeng Xu, Jing Zhao, Lin Ma, Yamei Wang, Uzma Majeed, Xu Liu, Rudi Appels, Marco Maccaferri, Roberto Tuberosa, Hongfeng Lu, Xueyong Zhang. Resequencing of 145 cultivars reveals asymmetric sub-genome selection and strong founder genotype effects on wheat breeding in China. Molecular Plant, 2020 Dec 7;13(12):1733-1751. Doi: 10.1016/j.molp.2020.09.001. (共同第一作者)

5. Chunhui Li^*, Honghui Guan^*, Xin Jing^*, Yaoyao Li^*, Baobao Wang^*, Yongxiang Li, Xuyang Liu, Dengfeng Zhang, Cheng Liu, Xiaoqing Xie, Haiyan Zhao, Yanbo Wang, Jingbao Liu, Panpan Zhang, Guanghui Hu, Guoliang Li, Suiyan Li, Dequan Sun, Xiaoming Wang, Yunsu Shi, Yanchun Song, Chengzhi Jiao^#, Jeffrey Ross-Ibarra^#, Yu Li^#, Tianyu Wang^# & Haiyang Wang^#. Genomic insights into historical improvement of heterotic groups during modern hybrid maize breeding. Nature Plants, 2022 Jul;8(7):750-763. Doi: 10.1038/s41477-022-01190-2. (共同通讯作者)

6. Ying-Hui Li^*, Chao Qin^*, Li Wang^*, Chengzhi Jiao^*, Huilong Hong, Yu Tian, Yanfei Li, Guangnan Xing, Jun Wang, Yongzhe Gu, Xingpeng Gao, Delin Li, Hongyu Li, Zhangxiong Liu, Xin Jing, Beibei Feng, Tao Zhao, Rongxia Guan, Yong Guo, Jun Liu, Zhe Yan, Lijuan Zhang, Tianli Ge, Xiangkong Li, Xiaobo Wang, Hongmei Qiu, Wanhai Zhang, Xiaoyan Luan, Yingpeng Han, Dezhi Han, Ruzhen Chang, Yalong Guo, Jochen C Reif, Scott A Jackson^#, Bin Liu^#, Shilin Tian^#, Li-Juan Qiu^#. Genome-wide signatures of the geographic expansion and breeding of soybean. Sci China Life Sci, 2023 Feb;66(2):350-365. Doi: 10.1007/s11427-022-2158-7. (共同第一作者)

7. Aijun Wang^*, Xinyue Shu^*, Xin Jing^*, Chengzhi Jiao^*, Lei Chen, Jinfeng Zhang, Li Ma, Yuqi Jiang, Naoki Yamamoto, Shuangcheng Li, Qiming Deng, Shiquan Wang, Jun Zhu, Yueyang Liang, Ting Zou, Huainian Liu, Lingxia Wang, Yubi Huang, Ping Li^#, Aiping Zheng^#. Identification of rice (Oryza sativa L.) genes involved in sheath blight resistance via a genome‐wide association study. Plant Biotechnology Journal, 2021 Aug;19(8):1553-1566. Doi: 10.1111/pbi.13569. (共同第一作者)

8. Hongwei Wang^*, Huayan Yin^*, Chengzhi Jiao^*, Xiaojian Fang^*, Guiping Wang, Guangrong Li, Fei Ni, Penghuan Li, Peisen Su, Wenyang Ge, Zhongfan Lyu, Shoushen Xu, Yanhong Yang, Yongchao Hao, Xinxin Cheng, Jinxiao Zhao, Cheng Liu, Fengfeng Xu, Xin Ma, Silong Sun, Yan Zhao, Yinguang Bao, Cheng Liu, Jingjing Zhang, Tomas Pavlicek, Anfei Li, Zujun Yang, Eviatar Nevo, Lingrang Kong. Sympatric speciation of wild emmer wheat driven by ecology and chromosomal rearrangements. Proc Natl Acad Sci USA, 2020 Mar 17;117(11):5955-5963. Doi: 10.1073/pnas.1920415117. (共同第一作者)

9. Haofeng Chen^*, Chengzhi Jiao^*, Ying Wang^*, Yuange Wang^*, Tian Caihuan, Yu Haopeng, Jing Wang, Xiangfeng Wang, Fei Lu, Xiangdong Fu, Yongbiao Xue, Wenkai Jiang, Hongqing Ling, Hongfeng lu, Yuling Jiao. Comparative population genomics of bread wheat (Triticum aestivum) reveals its cultivation and breeding history in China. bioRxiv, 2019: p. 519587. Doi: 10.1101/519587. (共同第一作者)

10. 张学勇，郝晨阳，焦成智，李甜，毛龙，刘旭。种质资源学与基因组学相结合-破解基因发掘与育种利用的难题。植物遗传资源学报， 2023, 24 (1): 11-21.

11. 马小定，崔迪，韩冰，焦成智^#，韩龙植^#。水稻种质资源全基因组DNA指纹鉴定方法研究。植物遗传资源学报，2022. doi: 10.13430/j.cnki.jpgr.20221221001.

12. Aili Li^*, Chenyang Hao^*, Zhenyu Wang^*, Shuaifeng Geng, Meiling Jia, Fang Wang, Xiang Han, Xingchen Kong, Lingjie Yin, Shu Tao, Zhongyin Deng, Ruyi Liao, Guoliang Sun, Ke Wang, Xingguo Ye, Chengzhi Jiao, Hongfeng Lu, Yun Zhou, Dengcai Liu, Xiangdong Fu^#, Xueyong Zhang^#, Long Mao^#. Wheat breeding history reveals synergistic selection of pleiotropic genomic sites for plant architecture and grain yield. Molecular Plant，2022 Mar 7;15(3):504-519. Doi: 10.1016/j.molp.2022.01.004.

13. Yao Zhou^*, Xuebo Zhao^*, Yiwen Li, Jun Xu, Aoyue Bi, Lipeng Kang, Daxing Xu, Haofeng Chen, Ying Wang, Yuan-ge Wang, Sanyang Liu, Chengzhi Jiao, Hongfeng Lu, Jing Wang, Changbin Yin, Yuling Jiao^# & Fei Lu^#. Triticum population sequencing provides insights into wheat adaptation. Nature Genetics, 2020, 52, 1412–1422. Doi: 10.1038/s41588-020-00722-w.

14. Chunhui Liu, Tianyi Wang, Huicha Chen, Xiaoding Ma, Chengzhi Jiao, Di Cui, Bing Han, Xiaobing Li, Aixia Jiao, Renchao Ruan, Dayuan Xue, Yanjie Wang, Longzhi Han. Genomic footprints of Kam Sweet Rice domestication indicate possible migration routes of the Dong people in China and provide resources for future rice breeding. Molecular Plant，2023 Feb 6;16(2):415-431. Doi: 10.1016/j.molp.2022.12.020.

15. Ning Guo, Shenyun Wang, Tianyi Wang, Mengmeng Duan, Mei Zong, Liming Miao, Shuo Han, Guixiang Wang, Xin Liu, Deshuang Zhang, Chengzhi Jiao, Hongwei Xu, Liyang Chen, Zhangjun Fei, Jianbin Li, Fan Liu. A graph-based pan-genome of Brassica oleracea provides new insights into its domestication and morphotype diversification. Plant Communications, 2024, 12;5(2):100791. Doi: 10.1016/j.xplc.2023.100791.

16. Zhiwei Wang, Chenyang Hao, Jing Zhao, Chang Li, Chengzhi Jiao, Wei Xi, Jian Hou, Tian Li, Hongxia Liu, Xueyong Zhang. Genomic footprints of wheat evolution in China reflected by a Wheat660K SNP array. The Crop Journal, Volume 9, Issue 1, 2021, Pages 29-41, ISSN 2214-5141. Doi: 10.1016/j.cj.2020.08.006.

17. Mingxing Wen, Jiaxuan Su, Chengzhi Jiao, Xu Zhang, Tao Xu, Tong Wang, Xiaoxue Liu, Zongkuan Wang, Li Sun, Chunxia Yuan, Haiyan Wang, Xiue Wang, Jin Xiao. Pleiotropic effect of the compactum gene and its combined effects with other loci for spike and grain related traits in wheat. Plants (Basel), 2022 Jul 13;11(14):1837. Doi: 10.3390/plants11141837.

18. Xin Lian, Yan Liu, Huihui Guo, Yijie Fan, Jianfei Wu, Haixia Guo, Chengzhi Jiao, Zhengmin Tang, Li Zhang, Yupeng Fan, Zhongyuan Gou, Changyu Zhang, Tongtong Li, Fanchang Zeng. Ethyl methanesulfonate mutant library construction in Gossypium hirsutum L. for allotetraploid functional genomics and germplasm innovation. The Plant Journal, 2020,103(2). Doi: 10.1111/tpj.14755.

19. Hongxia Liu, Xuemei Si, Zhenyu Wang, Liangjing Cao, Lifeng Gao, Xiaolong Zhou, Wenxi Wang, Ke Wang, Chengzhi Jiao, Lei Zhuang, Yunchuan Liu, Jian Hou, Tian Li, Chenyang Hao, Weilong Guo, Jun Liu, Xueyong Zhang. TaTPP-7A positively feedback regulates grain filling and wheat grain yield through T6P-SnRK1 signalling pathway and sugar-ABA interaction. Plant Biotechnol J, 2023;21(6):1159-1175. Doi:10.1111/pbi.14025.

20. Yiming Chen, Jialun Ji, Dehui Kong, Xiong Tang, Mingxing Wen, Guoqing Wang, Keli Dai, Peiyao Shi, Xu Zhang, Huajian Zhang, Chengzhi Jiao, Zongkuan Wang, Li Sun, Chunxia Yuan, Haiyan Wang, Xueyong Zhang, Bingjian Sun, Xinru Fei, Hong Guo, Jin Xiao & Xiue Wang. Resistance of QYm.nau-2D to wheat yellow mosaic virus was derived from an alien introgression into common wheat. Theor Appl Genet, 2023 Jan;136(1):3. Doi: 10.1007/s00122-023-04286-1.

21. Xu Zhang, Haiyan Wang, Haojie Sun, Yingbo Li, Yilong Feng, Chengzhi Jiao, Mengli Li, Xinying Song, Tong Wang, Zongkuan Wang, Chunxia Yuan, Li Sun, Ruiju Lu, Wenli Zhang, Jin Xiao, Xiue Wang. A chromosome-scale genome assembly of Dasypyrum villosum provides insights into its application as a broad-spectrum disease resistance resource for wheat improvement. Molecular Plant, 2023;16(2):432-451. Doi: 10.1016/j.molp.2022.12.021.

22. Aijun Wang, Yuqi Jiang, Xinyue Shu, Zhongping Zha, Desuo Yin, Yao Liu, Danhua Zhang, Deze Xu, Chengzhi Jiao, Xiaomei Jia, Xiaoying Ye, Shuangcheng Li, Qiming Deng, Shiquan Wang, Jun Zhu, Yueyang Liang, Ting Zou, Huainian Liu, Lingxia Wang, Jianqing Zhu, Ping Li, Zaijun Zhang, Aiping Zheng. Genome-wide association study-based identification genes influencing agronomic traits in rice (Oryza sativa L.) Genomics, 2021 May;113(3):1396-1406. Doi: 10.1016/j.ygeno.2021.03.016.

发明专利：

1、焦成智等，一种指纹图谱构建方法及系统。专利号：ZL 2023 1 0030065.X

2、焦成智等，一种泛基因组的构建方法、终端设备及存储介质。专利号：ZL 2023 1 1182329.X

3、焦成智等，一种基于泛基因组的基因区变异检测及可视化方法、系统。专利号：ZL 2023 1 1133414.7

焦成智 作物基因组学与分子设计育种课题组组长

焦成智作物基因组学与分子设计育种课题组组长