赵珺 生物微观结构研究平台负责人
研究方向：冷冻电镜方法学开发与应用
个人简介：
2012年9月-2018年6月，武汉理工大学材料科学与工程学院，本科硕士
2018年9月-2022年6月，燕山大学亚稳材料国家重点实验室，博士
2020年9月-2022年6月，中国科学院物理研究所，联合培养博士
2022年7月-至今，北京大学现代农业研究院，青年研究员，平台负责人
研究领域及成果：
基于先进电子显微镜技术开发相关方法和硬件，推进冷冻及原位电镜在多学科领域中的应用。1.冷冻电镜单颗粒及断层扫描重构技术在植物分子机制研究中的应用；2.冷冻及原位电镜核心部件/软件的开发应用；3.冷冻及原位电镜在交叉学科中的应用。
以第一作者（含共同一作）发表SCI一区论文18篇，包括Nature 4篇、Cell 1篇；以共同通讯作者身份在PNAS、Nature Communications、New Phytologist等期刊进行论文发表，目前论文总引用次数超过1600余次，获得山东省青年科技人才托举计划、山东省泰山学者青年专家等项目支持。
课题组招聘结构生物学、电子显微学方向科研助理、联培博士生及博士后等，欢迎联系！
代表性论文：
(#: Co-first author; *: Corresponding author)
1. Hao Xu#, Yimin Zhang#, Qinru Bai#, Lingli He#, Qihao Chen, Yunlong Qiu, Renjie Li, Jie Yu, Jun Zhao*, and Yan Zhao*. 2025. “Substrate and Inhibitor Binding of Human GABA Transporter 3.” Structure. doi:10.1016/j.str.2025.08.012.
2. Weidong An#, Yiwei Gao#, Laihua Liu, Qinru Bai, Jun Zhao*, Yan Zhao*, and Xuejun C. Zhang*. 2025. “Structural Basis of Urea Transport by Arabidopsis Thaliana DUR3.” Nature Communications 16(1):1782.
3. Zhanyi Xia#, Chuanyu Liu#, Di Wu#, Huiwen Chen, Jun Zhao*, and Daohua Jiang*. 2025. “Structural Insights into Glucose-6-Phosphate Recognition and Hydrolysis by Human G6PC1.” Proceedings of the National Academy of Sciences 122(4):e2418316122.
4. Cheng Chi#, Xinlin Chen#, Changan Zhu, Jiajian Cao, Hui Li, Ying Fu, Guochen Qin, Jun Zhao*, Jingquan Yu, and Jie Zhou*. 2025. “Strigolactones Positively Regulate HY5-Dependent Autophagy and the Degradation of Ubiquitinated Proteins in Response to Cold Stress in Tomato.” New Phytologist 245(3):1106–23.
5. Zhengdong Wang#, Wenfeng Wang#, Didi Zhao#, Yanping Song#, Xiaoli Lin#, Meng Shen, Cheng Chi, Bin Xu, Jun Zhao, Xing Wang Deng*, and Jizong Wang*. 2024. “Light-Induced Remodeling of Phytochrome B Enables Signal Transduction by Phytochrome-Interacting Factor.” Cell 187(22):6235–50.
6. Tuo Hu#, Zhuoya Yu#, Jun Zhao#, Yufei Meng, Kristine Salomon, Qinru Bai, Yiqing Wei, Jinghui Zhang, Shujing Xu, Qiuyun Dai, Rilei Yu, Bei Yang, Claus J. Loland*, and Yan Zhao*. 2024. “Transport and Inhibition Mechanisms of the Human Noradrenaline Transporter.” Nature. doi: 10.1038/s41586-024-07638-z.
7. Yue Li#, Xianping Wang#, Yufei Meng#, Tuo Hu#, Jun Zhao#, Renjie Li, Qinru Bai, Pu Yuan, Jun Han, Kun Hao, Yiqing Wei, Yunlong Qiu, Na Li, and Yan Zhao*. 2024. “Dopamine Reuptake and Inhibitory Mechanisms in Human Dopamine Transporter.” Nature. doi:10.1038/s41586-024-07796-0.
8. Rui Yan#, Huiwen Chen#, Chuanyu Liu#, Jun Zhao#, Di Wu, Juquan Jiang, Jianke Gong, and Daohua Jiang*. 2024. “Human XPR1 Structures Reveal Phosphate Export Mechanism.” Nature. doi: 10.1038/s41586-024-07852-9.
9. Di Wu#, Qihao Chen#, Zhuoya Yu#, Bo Huang#, Jun Zhao#, Yuhang Wang, Jiawei Su, Feng Zhou, Rui Yan, Na Li, Yan Zhao*, and Daohua Jiang*. 2024. “Transport and Inhibition Mechanisms of Human VMAT2.” Nature 626(7998).
10. Yiqing Wei#, Renjie Li#, Yufei Meng#, Tuo Hu#, Jun Zhao#, Yiwei Gao, Qinru Bai, Na Li, and Yan Zhao*. 2024. “Transport Mechanism and Pharmacology of the Human GlyT1.” Cell 187(7).
11. Di Wu#, Zhuoya Yu#, Qihao Chen#, Jun Zhao#, Bo Huang, Yuhang Wang, Jiawei Su, Na Li, Daohua Jiang*, and Yan Zhao*. 2024. “Structural Snapshots of Human VMAT2 Reveal Insights into Substrate Recognition and Proton Coupling Mechanism.” Cell Research 34(8):586–89.
12. Yuxuan Zhang#, Xiaoli Lin#, Chengying Ma#, Jun Zhao#, Xiaojin Shang, Zhengdong Wang, Bin Xu, Ning Gao, Xing Wang Deng*, and Jizong Wang*. 2023. “Structural Insights into Plant Phytochrome A as a Highly Sensitized Photoreceptor.” Cell Research 33(10):806–9.
13. Jun Zhao#, Chao Zhao#, Jianping Zhu, Xiangsi Liu, Jingming Yao, Bo Wang, Qiushi Dai, Zaifa Wang, Jingzhao Chen, Peng Jia, Yanshuai Li, Stephen J. Harris, Yong Yang, Yongfu Tang*, Liqiang Zhang*, Feng Ding*, and Jianyu Huang*. 2022. “Size-Dependent Chemomechanical Failure of Sulfide Solid Electrolyte Particles during Electrochemical Reaction with Lithium.” Nano Letters 22(1):411–18.
14. Jun Zhao#, Yongfu Tang#, Qiushi Dai#, Congcong Du, Yin Zhang, Dingchuan Xue, Tianwu Chen, Jingzhao Chen, Bo Wang, Jingming Yao, Ning Zhao, Yanshuai Li, Shuman Xia, Xiangxin Guo, Stephen J. Harris, Liqiang Zhang*, Sulin Zhang*, Ting Zhu*, and Jianyu Huang*. 2022. “In Situ Observation of Li Deposition-Induced Cracking in Garnet Solid Electrolytes.” Energy & Environmental Materials 5(2):524–32.
15. Qiushi Dai#, Jun Zhao#, Hongjun Ye, Jingzhao Chen, Yong Su, Tingting Yang, Qiunan Liu, Haiming Sun, Hui Li, Jingming Yao, Zhiying Gao, Xingjie Fu, Dingding Zhu, Jitong Yan, Mingyu Li, Hailong Qiu, Qiao Huang, Liqiang Zhang, Yongfu Tang, Xiangxin Guo, and Jianyu Huang*. 2021. “Ultrastable Anode/Electrolyte Interface in Solid-State Lithium-Metal Batteries Using LiCux Nanowire Network Host.” ACS Applied Materials & Interfaces 13(36):42822–31.
16. Jianping Zhu#, Jun Zhao#, Yuxuan Xiang, Min Lin, Hongchun Wang, Bizhu Zheng, Huajin He, Qihui Wu, Jian Yu Huang*, and Yong Yang*. 2020. “Chemomechanical Failure Mechanism Study in NASICON-Type Li1.3Al0.3Ti1.7(PO4)3 Solid-State Lithium Batteries.” Chemistry of Materials 32(12):4998–5008.
17. Jian Zou#, Jun Zhao#, Bojun Wang#, Shulin Chen, Pengyu Chen, Qiwen Ran, Li Li, Xin Wang, Jingming Yao, Hong Li, Jianyu Huang*, Xiaobin Niu*, and Liping Wang*. 2020. “Unraveling the Reaction Mechanism of FeS2 as a Li-Ion Battery Cathode.” ACS Applied Materials & Interfaces 12(40):44850–57.