赵丽华   环境与植物生殖发育课题组

个人简介：

2015. 9 —2018.6 ：  福建农林大学 细胞生物学 博士

2007. 9 —2010.7 ：  兰州大学 植物学专业 硕士

2003. 9 —2007.7 ：  山东临沂师范学院生物技术专业 学士

工作经历：

2010. 7 —2014.6 ：  中科院上海植物生理生态研究所 助研

2014. 6 —2019.12： 福建农林大学海峡联合研究院 助研

2020. 1 —2023.12： 瑞典农业科学大学 博士后

2024. 1 — 至今    ：  北京大学现代农业研究院，青年研究员 ，泰山学者青年专家

重要荣誉及奖励：

2021年获玛丽居里学者

2019年获福建省优秀博士论文奖

2018年获中国植物生理学会-优秀青年女科学家奖

主要研究领域：

    随着全球气候变暖，极端恶劣天气情况越来越频繁出现，植物必须面临更严重、更频繁的高温胁迫。植物生长、发育等各个方面必然也越来越多地受到高温胁迫的影响。值得关注的是，植物开花、受精、胚胎发育等有性生殖发育过程更容易受到高温胁迫的影响。而植物尤其是作物的生殖发育同当前我们面对的严峻的粮食安全问题紧密相关。

本实验室以拟南芥和大豆为模式植物，研究极端气候环境对植物生殖发育影响的分子机制。利用细胞生物学、分子生物学、遗传学和其他技术的整合，来阐明在不同的生物和非生物胁迫背景下控制雌配子体形成和分化的遗传途径，为开发高产和抗逆新作物品种提供理论依据。此外，本实验室还致力于改进whole mount-smFISH技术及其在植物生物学研究中的应用。

研究方向：

1高温影响植物雌性生殖系细胞特化的遗传和表观遗传学机制

2高温下大豆生殖发育关键调控基因的鉴定与功能解析

3 smFISH技术的改进和其在大豆生殖发育研究中的应用

发表论文 :  

1.     Zhao L^#, Fonseca A^#, Meschichi A, Sicard A^*, Rosa S^*. 2023. Whole-mount smFISH allows combining RNA and protein quantification at cellular and subcellular resolution. Nat Plants, 9(7):1094-1102.

2.     Zhao L^#, Liu L^#, Liu Y^#, Dou X, Cai H, Aslam M, Hou Z, Jin X, Li Y, Wang L, Zhao H, Wang X, Sicard A, Qin Y^*. 2021. Characterization of germline development and identification of genes associated with germline specification in pineapple. Hortic Res, 8(1):239.

3.     Zhao L^#, Cai H^#, Su Z^#, Wang L, Huang X, Zhang M, Chen P, Dai X, Zhao H, Palanivelu R, Chen X^*, Qin Y^*. 2018. KLU suppresses megasporocyte cell fate through SWR1-mediated activation of WRKY28 expression in Arabidopsis. Proc Natl Acad Sci U S A, 115(3):E526-E535.

4.     Cai H^#, Zhao L^#, Wang L, Zhang M, Su Z, Cheng Y, Zhao H, Qin Y^*. 2017. ERECTA signaling controls Arabidopsis inflorescence architecture through chromatin-mediated activation of PRE1 expression. New Phytol, 214(4):1579-1596.

5.     Su Z^#, Zhao L^#, Zhao Y, Li S, Won S, Cai H, Wang L, Li Z, Chen P, Qin Y^*, Chen X^*. 2017. The THO Complex Non-Cell-Autonomously Represses Female Germline Specification through the TAS3-ARF3 Module. Curr Biol, 27(11):1597-1609 e1592.

6.     Dai X^#, Bai Y^#, Zhao L^#, Dou X^#, Liu Y, Wang L, Li Y, Li W, Hui Y, Huang X, Wang Z, Qin Y^*. 2017. H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis. Mol Plant, 10(10):1274-1292.

7.     Zhao L^#, He J, Cai H, Lin H, Li Y, Liu R, Yang Z, Qin Y^*. 2014. Comparative expression profiling reveals gene functions in female meiosis and gametophyte development in Arabidopsis. Plant J, 80(4):615-628.

8.     Meschichi A, Zhao L, Reeck S, White C, Da Ines O, Sicard A, Pontvianne F, Rosa S^*. 2022. The plant-specific DDR factor SOG1 increases chromatin mobility in response to DNA damage. EMBO Rep, 23(12):e54736.

9.     Antoniou-Kourounioti R L, Meschichi A, Reeck S, Berry S, Menon G, Zhao Y, Fozard J, Holmes T, Zhao L, Wang H, Hartley M, Dean C, Rosa S^*, Howard M^*. 2023. Integrating analog and digital modes of gene expression at Arabidopsis FLC. Elife, 12.

10.   Hou Z, Liu Y, Zhang M, Zhao L, Jin X, Liu L, Su Z, Cai H, Qin Y^*. 2021. High-throughput single-cell transcriptomics reveals the female germline differentiation trajectory in Arabidopsis thaliana. Commun Biol, 4(1):1149.

11.   Zhang X, Wang G, Zhang S, Chen S, Wang Y, Wen P, Ma X, Shi Y, Qi R, Yang Y, Liao Z, Lin J, Lin J, Xu X, Chen X, Xu X, Deng F, Zhao L, Lee Y L, Wang R, Chen X Y, Lin Y R, Zhang J, Tang H, Chen J, Ming R^*. 2020. Genomes of the Banyan Tree and Pollinator Wasp Provide Insights into Fig-Wasp Coevolution. Cell, 183(4):875-889 e817.

12.   Liu L, Zhao L, Chen P, Cai H, Hou Z, Jin X, Aslam M, Chai M, Lai L, He Q, Liu Y, Huang X, Chen H, Chen Y, Qin Y^*. 2020. ATP binding cassette transporters ABCG1 and ABCG16 affect reproductive development via auxin signalling in Arabidopsis. Plant J, 102(6):1172-1186.

13.   Wang L, Li Y, Jin X, Liu L, Dai X, Liu Y, Zhao L, Zheng P, Wang X, Liu Y, Lin D, Qin Y^*. 2020. Floral transcriptomes reveal gene networks in pineapple floral growth and fruit development. Commun Biol, 3(1):500.

14.   Cai H, Zhang M, Chai M, He Q, Huang X, Zhao L, Qin Y^*. 2019. Epigenetic regulation of anthocyanin biosynthesis by an antagonistic interaction between H2A.Z and H3K4me3. New Phytol, 221(1):295-308.

15.   Cao L, Wang S, Venglat P, Zhao L, Cheng Y, Ye S, Qin Y, Datla R, Zhou Y, Wang H^*. 2018. Arabidopsis ICK/KRP cyclin-dependent kinase inhibitors function to ensure the formation of one megaspore mother cell and one functional megaspore per ovule. PLoS Genet, 14(3):e1007230.