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Hang He’s Team and Xing Wang Deng's Team Collaboratively Report the Nucleosome-Resolution Chromatin High-Order Structure in Plants, with its Molecular Mechanism Analyzed

On January 2, 2024, the research teams of Academician Xing Wang Deng and Professor Hang He from the Peking University Institute of Advanced Agricultural Sciences, published a research paper in Nature Communications, titled "Mapping nucleosome-resolution chromatin organization and enhancer-promoter loops in plants using Micro-C-XL". They improved and utilized the chromatin conformation capture technique Micro-C-XL with nucleosome resolution, and reported for the first time super high-resolution chromatin interaction maps in plants. With this methodology, they revealed high-precision chromatin structural domains and chromatin loops, and analyzed the molecular mechanisms through which RNA polymerases II, IV, and V regulate chromatin structure.

 

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