Principal Investigator
Principal Investigator
Dr.Yuehui He
Contact Address: No. 699 Binhu Road, Fangzi District, Weifang, Shandong, China
Email: yuehui.he@pku-iaas.edu.cn
Education
Ph.D. (2001), The University of Kentucky, USA
Working Experience
2020-now, Senior Principal Investigator, Peking University Institute of Advanced Agricultural Sciences, China
2020-now, Professor, School of Advanced Agricultural Sciences & Peking-Tsinghua Center for Life Sciences, Peking University, China
2014-2020, Senior Principal Investigator, Shanghai Center for Plant Stress Biology, Chinese Academy of Sciences, China
2012-2014, Associate Professor (tenured), Department of Biological Sciences, National University of Singapore, Singapore
2012-2014, Senior Principal Investigator, Temasek Life Sciences Laboratory, Singapore
2006-2011, Principal Investigator, Temasek Life Sciences Laboratory, Singapore
2005-2011, Assistant Professor, Department of Biological Sciences, NationalUniversity of Singapore, Singapore
2001-2005, Postdoctoral Research Associate, Department of Biochemistry,
University of Wisconsin-Madison, USA
Research Interests
l Plant environmental epigenetics
l Molecular epigenetic mechanisms for vernalization and flowering-time regulation
l Crop genetic improvement of flowering time
Selected Publications
Huang F, Luo X, Ou Y, Gao Z, Tang Q, Chu Z, Zhu X and He Y. (2023) Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase. Science 381: eadf8822.
Zhang Z, Luo X, Yang, Y and He Y. (2023) Cold induction of nuclear FRIGIDA condensation in Arabidopsis. Nature 7969: E27-E32.
Gao Z, Li Y, Ou Y, Yin M, Chen T, Zeng X, Li R and He Y. (2023) A pair of readers of bivalent chromatin mediate formation of Polycomb-based "memory of cold" in plants. Molecular Cell 83: 1109-1124.
Xu G, Tao Z and He Y. (2022) Embryonic reactivation of FLOWERING LOCUS C by ABSCISIC ACID-INSENSITIVE 3 establishes the vernalization requirement in each Arabidopsis generation. Plant Cell 34: 2205-2221.
Li Z, Luo X, Ou Y, Jiao H, Peng L, Fu X, Macho AP, Liu R and He Y. (2021) JASMONATE-ZIM DOMAIN proteins engage Polycomb chromatin modifiers to modulate Jasmonate signaling in Arabidopsis. Molecular Plant, 14: 732-747.
Luo X, Ou Y, Li R and He Y. (2020) Maternal transmission of the epigenetic 'memory of winter cold' in Arabidopsis. Nature Plants 6: 1211-1218.
Tao Z, Hu H, Luo X, Jia B, Du J and He Y. (2019) Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis. Nature Plants 5: 424-435.
Luo X, Chen T, Zeng X, He D and He Y. (2019) Feedback regulation of FLC by FLOWERING LOCUS T and FD through a 5' FLC promoter region. Molecular Plant 12: 285-288.
LiZ, Jiang D and He Y. (2018) FRIGIDA establishes a local chromosomal environment for FLOWERING LOCUS C mRNA production. Nature Plants 4: 836-846.
LiZ, FuX, WangY, LiuR and He Y. (2018) Polycomb-mediated gene silencing by the BAH-EMF1 complex in plants. Nature Genetics 50: 1254-1261.
He Y. and Li Z. (2018) Epigenetic environmental memories in plants: establishment, maintenance, and reprogramming. Trends in Genetics 34: 856-866.
Li Z, Ou Y, Zhang Z, Li L andHe Y. (2018) Brassinosteroid signaling recruits Histone 3 lysine-27 demethylation activity to FLOWERING LOCUS C chromatin to inhibit the floral transition in Arabidopsis. Molecular Plant 11: 1135-1146.
Tao Z, Shen L, Gu X, Wang Y, Yu H and He Y. (2017) Embryonic epigenetic reprogramming by a pioneer transcription factor in plants. Nature551: 124–128.
Yuan W, Luo X, Li Z, Yang W, Wang Y, Liu R, Du J and He Y. (2016) A cis cold memory element and a trans epigenome reader mediate Polycomb silencing of FLC by vernalization in Arabidopsis. Nature Genetics 48: 1527-1534.
Li Z, Jiang D, Fu X, Luo X, Liu R and He Y. (2016) Integration of histone methylations with RNA processing by the nuclear mRNA Cap Binding Complex. Nature Plants 2: 16015.
Wang Y., Gu X., Yuan W., Schmitz R. and He Y. (2014) Photoperiodic control of the floral transition through a distinct Polycomb repressive complex. Developmental Cell 28: 727-736.
Gu X, Le C, Wang Yi, Li Z, Jiang D, Wang Yu and He Y. (2013) Arabidopsis FLC clade members form flowering-repressor complexes coordinating responses to endogenous and environmental cues. Nature Communications 4 (1947): 1-10.
He Y. (2012) Chromatin regulation of flowering (invited review). Trends in Plant Science 17: 556-562.