Principal Investigator

Dr.Li Guo

Contact Address: No. 699 Binhu Road, Fangzi District, Weifang, Shandong, China

Email: li.guo@pku-iaas.edu.cn

Education

2006-2012, PhD in Plant Pathology, The Pennsylvania State University, USA

2002-2006, BS in Plant Protection, Northwest A&F University, China

Working Experience

2021-now, Principal Investigator, Peking University Institute of Advanced Agricultural Sciences, China

2020-2021, Professor, Xi 'an Jiaotong University, China

2016-2020, Associate Professor, Xi 'an Jiaotong University, China

2012-2016, Postdoctoral Research, University of Massachusetts Amherst, USA

Research Interests

l Genomics and bioinformatics of horticulture plants

l Synthetic biology of plant and fungal natural products

l Chemical biology of plant-microorganism interactions

Selected Publications

Articles

Wang X^#, Li H^#, Shen T, Wang X, Yi S, Meng T, Sun J, Wang X, Qu X, Chen S*, Li Guo*. (2023) A near-complete genome sequence of einkorn wheat provides insight into the evolution of wheat A subgenomes. Plant Communications https://doi.org/10.1016/j.xplc.2023.100768

Liu H, Wang H, Liao XL, Gao B, Lu X, Sun D, Gong W, Zhong J, Zhu H, Pan X, Guo L*, Deng XW* and Zhou Q*. (2022) Mycoviral gene integration converts a plant pathogenic fungus into a biocontrol agent. Proc Natl Acad Sci USA 119(50): e2214096119

Guo L^#, Winzer T^#, Yang X^#, Li Y^#, Ning Z^#, He Z, Teodor R, Lu Y, Bowser TA, Graham IA*, Ye K* (2018) The opium poppy genome and morphinan production. Science362(6412): 343-347.

Wang J^#, Li J*^#, Li Z, Liu B, Zhang L, Guo D, Huang S, Qian W*, Guo L*. (2022) Genomic insights into longan evolution from a chromosome-level genome assembly and population genomics of longan accessions. Horticulture Research9: uhac021.

Guo L*^#, Yao Hui^#, Chen W^#, Wang X, Ye P, Xu Z, Zhang S, Wu H*. (2022) Natural products of medicinal plants: biosynthesis and bioengineering in post-genomic era, Horticulture Research 9: uhac223.

Yao G, Chen W, Sun J, Wang X, Wang H, Meng T, Zhang L &Guo L*. (2023). Gapless genome assembly of Fusarium verticillioides, a filamentous fungus threatening plant and human health. Scientific Data 10(1): 229. https://doi.org/10.1038/s41597-023-02145-8

Yang X^#, Gao S^#, Guo L^#, Wang B, Jia Y, Zhou J, Che Y, Jia P, Lin J, Xu T, Sun J, Ye K*. (2021) Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway. Nature Communications 12:6030

Guo L^#,Yu H^#, Wang B^#, Vescio K, Delulio G, Yang H, Berg A, Zhang L, Edel-Hermann V, Steinberg C, Kistler HC, Ma LJ* (2021) Metatranscriptomic comparison of endophytic and pathogenic Fusarium-Arabidopsis interactions reveals plant transcriptional plasticity. Molecular Plant-Microbe Interactions 34(9):1071-1083

Wang B^#, Yu H, Jia Y, Dong Q, Steinberg C, Alabouvette CL, Edel-Hermann V, Kistler HC, Ye K*, Ma LJ*, and Guo L*. (2020) Chromosome-scale genome assembly of Fusarium oxysporum strain Fo47, a fungal endophyte and biocontrol agent. Molecular Plant-Microbe Interactions 33(9), p.1108-1111

Guo L^#*, Ji M^#, and Ye K*. (2020) Dynamic network inference and association computation discover gene modules regulating virulence, mycotoxin production and sexual reproduction in Fusarium graminearum. BMCGenomics 21:179 

Fokkens L^#, Guo L^#, Dora S, Wang B, Ye K* Sánchez-Rodríguez C*, Croll D*. (2020) A chromosome-scale genome assembly for the Fusarium oxysporumstrain Fo5176 to establish a model Arabidopsis-fungal pathosystem. G3: Genes, Genomes, Genetics 10(10), p.3549-3555

Wang B^#, Guo L^#, Ye K*, Wang L* (2020) Chromosome-scale genome assembly of Talaromycesrugulosus strain W13939, a mycoparasitic fungus and promising biocontrol agent. Molecular Plant-Microbe Interactions 33(12):1446-1450.

Guo L^#, Zhao G, Gao L, Xu JR, Kistler HC, Ma LJ*. (2016) Compartmentalized gene regulatory network of a pathogenic fungus Fusarium graminearum. New Phytologist 211(2): 527-541.

Guo L^#, Breakspear A, Zhao G, Gao L, Kistler HC, Xu JR, Ma LJ*. (2016) Conservation and divergence of the cyclic adenosine monophosphate–protein kinase A (cAMP–PKA) pathway in two plant-pathogenic fungi: Fusarium graminearum and F. verticillioides. Molecular Plant Pathology 17(2): 196-209.

Book chapters

Guo L^#and Ma LJ*(2014) Fusarium graminearumGenomics and Beyond. Genomics of Plant-Associated Fungi: Monocot Pathogens, eds Dean RA, Lichens-Park A, & Kole C (Springer Berlin Heidelberg), pp 103-122.

Zhang Y^#, Guo L, Ma LJ*. (2018) A computational protocol to analyze metatranscriptomic data capturing fungal–host interactions. Wenbo Ma and Thomas Wolpert (eds.), Plant Pathogenic Fungi and Oomycetes. Methods in Molecular Biology 1848:207-233

Ye K*^#, Guo L, Yang X, Lamijer EW, Raine K, Ning Z. (2018) Split-Read Indel and Structural Variant Calling Using PINDEL. Derek Bickhart (ed.), Copy Number Variants: Methods and Protocols, Methods in Molecular Biology1833:95-105.

Honorables and Awards

2022 Taishan Scholar of Shandong Province

2022 Excellent reviewer of Chinese Scientific Journal Excellence Action Plan, China Association for Science and Technology

2021 Yuandu Scholar of Weifang City

2020 High-level Returned Overseas Talents, Ministry of Human Resources and Social Security of PRC

2019 The Fifth “Top 10 Academic New Talents” of Xi'an Jiaotong University