Principal Investigator

Dr. Yan Xue

Contact Address: No. 699 Binhu Road, Fangzi District, Weifang, Shandong, China

Email: yan.xue@pku-iaas.edu.cn

Education

2009 – 2017  Ph.D. Department of Biology, Duke University, USA

2007 – 2009  M.Sc. Department of Molecular Biotechnology, The Chinese University of Hong Kong

2003 – 2007  B.S. Department Biology, The Chinese University of Hong Kong

Working Experience

2022 – present Principle Investigator, Peking UniversityInstitute of Advanced Agricultural Sciences, China

2017 – 2022  Postdoctoral fellow,Department of Molecular, Cell & Developmental Biology,  University of California, Los Angles, USA

2009 – 2017  Ph.D.,  Department of Biology, Duke University, USA

2007 – 2009  M.Sc., Department of Molecular Biotechnology, The Chinese University of Hong Kong

Selected Publications

Zhong, Z.*,Xue, Y.*,Harris CJ.*; Wang, M., Li, Z., Ke, Y.,Jami-Alahmadi, Y., Feng, S.,Wohlschlegel, J.and Jacobsen, SE. MORC proteins regulatetranscription factor binding by mediating chromatin compaction in active chromatin regions. (2023) Genome Biology 24:96.

Wang, Q.,* Xue, Y.,* Zhang, L.,* Zhong, Z., Feng, S., Wang, C., Xiao, L., Yang, Z., Harris, CJ., Wu, Z., Zhai, J.,Yang, M., Li, S., Jacobsen, SE. and Du, J. (2021) Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science 374:1152-1157.

Xue, Y.*, Zhong Z.*, Harris CJ.*, Gallego-Bartolomé, J., Wang, M., Picard, C., Cao, X., Hua, S., Kwok, I., Feng, S., Jami-Alahmadi, Y., Sha, J., Gardiner, J., Wohlschlegel, J. and Jacobsen, SE. (2021) Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation. Nature Communications12:4292.

Jiang, Z., Zhou, X., Tao, M., Yuan, Y., Liu, L., Wu, F., Wu, X., Xiang, Y., Niu, Y., Liu, F., Li, C., Ye, R., Byeon, B., Xue, Y., Zhao, H., Wang, S., Crawford, B., Johnson, M., Hu, C., Pei, C., Zhou, W., Swift, G., Zhang, H., Vo-Dinh, T., Hu, Z., Siedow, J. and Pei, Z. (2019) Plant cell-surface GIPC sphingolipids sense salt to trigger Ca²⁺ influx. Nature 572: 341-346.

Kim, HJ., Yen, L, Wongpalee, SP., Kirshner, JA., Mehta, N., Xue, Y., Johnston, JB., Burlingame, AL., Kim, JK., Loparo JJ., and Jacobsen, SE. (2019). The Gene silencing protein MORC-1 topologically entraps DNA and forms multimeric assemblies to cause DNA compaction. Molecular Cell 75: 700-71

Harris, CJ., Scheibe, M., Wongpalee, SP., Liu, W., Cornett, EM., Vaughan, RM., Li, X., Chen, W., Xue, Y., Zhong, Z., Yen, L., Barshop, WD., Rayatpisheh, S., Gallego-Bartolome, J., Groth, M., Wang, Z., Wohlschlegel, JA., Du, J., Rothbart, SB., Butter, F., and Jacobsen, SE. (2018). A DNA methylation reader complex that enhances gene transcription. Science6419: 1182-1186.

Yuan, F., Yang, H.*; Xue, Y.*; Kong, D., Ye, R., Li, C., Zhang, J., Theprungsirikul, L.,

Shrift, T., Krichilsky, B., Johnson, DM., Swift, GB., He, Y., Siedow, JN. and Pei, ZM.

(2014). OSCA1 mediates osmotic-stress-evoked Ca²⁺increases vital for osmosensing in

Arabidopsis. Nature 514: 367-371

Jiang, Z., Zhu, S., Ye, R.,Xue, Y., Chen, A., An, L. and Pei, ZM.(2013). Relationship between NaCl^- and H2O2-Induced cytosolic Ca²⁺Increases in response to stress in Arabidopsis. PLoS ONE 8: 10

Cheung, MY., Xue, Y., Zhou, L., Li, MW., Sun, SSM. and Lam, HM. (2010) An ancient Ploop GTPase in rice is regulated by a higher plant-specific regulatory protein.Journal of Biololgical Chemistry285:37359–37369.

Cheung, MY., Zeng, NY., Tong, SW., Li, FWY., Xue, Y., Zhao, KJ., Wang, C., Zhang, Q., Fu, Y., Sun, Z., Sun, SSM. and Lam, HM. (2008) Constitutive expression of a rice GTPase activating protein induces defense responses. New Phytologist179:530-545

Honorables and Awards

National: National Postdoctoral Fellowship Program (海外博后引才计划)

Shandong Province: Taishan Scholars Program of Shandong Province(泰山青年学者)

Shandong Province: Selected Providential Talent (山东省海外优青)